An ancient pre-Columbian Native-American historic site, the Sewee Shell Mound is accessed by a hiking trail in Francis Marion National Forest. Visitors may begin their tour at the Sewee Visitor and Environmental Education Center, located at 5821 U.S. 17 North, in the town of Awendaw.

Historic Bull Island and the Cape Romain National Wildlife Refuge offer a unique combination of South Carolina history and natural history. Bull Island was frequented by the pirates of the Colonial Era, by British sailors in the Revolution, and Northern troops in the Civil War. Ferry transportation and tours may be arranged through Refuge headquarters.

The oldest museum in the United States, the Charleston Museum was established in 1773. Its numerous exhibits, displays and artifacts survey South Carolina's rich history and culture.

The visible remains of the fort the British built on top of a Native-American mound on the banks of the Santee river is situated here. Marion laid siege on Fort Watson in April 1781, when one of his subordinates, Lieutenant Colonel Maham, proposed building a tower under the cover of night from which they fired direct rifle fire into the fort.

A 2,725-acre preserve and wildlife area, the Great Pee Dee River Heritage Preserve and Wildlife Management Area preserves a seven-mile stretch of the historic Great Pee Dee River in its natural state. It is managed by the S.C. Department of Natural Resources.

The Horry County Museum is located on Main Street, in downtown Conway, and features a variety of well-designed exhibits that chronicle the colorful history of Horry County. Permanent exhibits focus on local Native American culture, the timber industry and naval stores operations.

Little Pee Dee State Park is reminiscent of the woodlands and swamplands that covered much of the Pee Dee Region from the time it was inhabited solely by Native Americans through the 19th century.

One of the oldest coastal communities in South Carolina, Little River attracted English colonists as early as the 1730s. Today it is best known for its local seafood and access to the Intracoastal Waterway.

Clustered around the Socastee Swing Bridge which spanned the last link of the Intracoastal Waterway in 1936, the Socastee Historic District includes Socastee United Methodist Church, established in 1818, a landmark pecan grove, various historic homes, and the T.B. Cooper General Store, built in 1905, which served as the first post office for the fledgling resort of Myrtle Beach.

Located at the Myrtle Beach Convention Center on North Oak Street in Myrtle Beach, the South Carolina Hall of Fame consists of an extensive lobby display commemorating historical and contemporary South Carolinians of note. Popular with school and tour groups, it is open daily to the general public.

Historical exhibits and artifacts ranging from the prehistoric to the present are displayed at the Florence Museum, including extensive collections of art. Among the highlights: the Francis A. Lord Collection of Civil War Artifacts, exhibits on local and South Carolina history, the World War Hall, artifacts and displays related to slavery and African American culture, and ancient art and artifacts from throughout the world.

Managed by the U.S. Fish and Wildlife Service, Waccamaw National Wildlife Refuge is composed of 54,000 acres of undeveloped land on the Waccamaw, Great Pee Dee and Little Pee Dee Rivers, with a state-of-the-art nature center overlooking Yauhannah Lake on the Great Pee Dee River off U.S. 701, approximately 15 miles south of Conway.

Housed in a Carnegie Library built in 1917, the Williamsburgh Historical Museum in Kingstree features displays and exhibits relating to Williamsburg County's rich history and artifacts from the region's Native American era, Colonial Period, the Revolution, the South Carolina slave culture, agriculture, the military and other topics related to local history.